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In contrast R proteins bind cobalamin less avidly and undergo proteolysis when they come into exposure to the more alkaline environment of the small intestine (SI) (72)

However, evidence of the efficacy of enhanced control of glycemia in preventing neuropathy is stronger in patients with type 1 diabetes than in those with type 2 diabetes (73)

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ScienceDirect Al Qassab M, et al

J Mater Chem B 3(39):77247733